Terpenes 101: Caryophyllene Terpenes 101: Caryophyllene

Terpenes 101: Caryophyllene

Posted by Tweedle Farms on Aug 5th 2022

Terpene blog cover

As we navigate our natural world, we encounter numerous aromas; some good, some bad.

Plants are capable of exuding a vast array of smells, from the sharp and pungent, to the sweet and seductive. This variety is due, in part, to aromatic compounds called terpenes that are found in plant resins.

Not only are terpenes responsible for brightening our world with their aromas, they’re also known for a variety of medicinal benefits. For example, the effects of aromatherapy are largely due to terpenes, as are certain medicinal properties of plants and natural medicine. As you’ll see in the chart at the bottom of the page, each terpene holds its own beneficial properties.

As if that weren’t enough, terpenes also play a large role in determining the effects of cannabis! Without terpenes, cannabinoids like CBD and THC would have relatively muted effects, but when they’re combined with these miraculous aromatic compounds - that’s when the magic happens; and more pointedly, it’s when the true difference between strains considered “indica” or “sativa” can be felt.

What is Caryophyllene (aka beta caryophyllene or β-caryophyllene)?

Caryophyllene, more frequently known as β-caryophyllene, is one of the more common terpenes found in cannabis. It’s also found in large concentrations in black pepper, cloves, hops, rosemary and a variety of other plants.

What Does Caryophyllene Smell LIke?

Known for its spicy, musky, and funky profile, it is the terpene largely responsible for the spiciness of black pepper. It also contributes a similarly spicy and pungent flavor to cannabis as well as hop-heavy beers, like IPAs.

Strains High in Caryophyllene

Many of our favorite strains are positively packed with terpenes, including bestsellers like Mango PieOG KushKush Hemp, and Pinewalker. THC-rich strains Girl Scout Cookies and Gelato are also high in caryophyllene.

Caryophyllene Effects

What does caryophyllene do?

Caryophyllene is an extremely interesting terpene because its chemical structure allows it to bond directly with the body’s CB2 cannabinoid receptor. β-caryophyllene has, in fact, been established as a "full agonist" of the CB2 receptor by numerous studies performed over the last few years.

In one study from 2022, it was also found that β-caryophyllene was able to activate, and subsequently desensitize, another pathway shared with cannabinoids: the TRPV1 ion channel. TRPV1 is responsible for the detection and regulation of body temperature, as well as the sensations of scalding heat and pain.

These unique properties have earned β-caryophyllene the title of the "first known dietary cannabinoid," because unlike other terpenes, it acts like a cannabinoid and is capable of activating our endocannabinoid system!

Curious how that can manifest and what kind of effects it can produce? Check out this terpene chart from Green Leaf Labs: